| Ecosystem | Type | Status | Ref. |
|---|---|---|---|
| Arkansas River | River (basin) | native | 5723 |
| Chesapeake Bay | Sea/Bay/Gulf | Native | 93252 |
| Great Lakes | Lake | native | 10294 |
| Hudson River | River (basin) | native | 27549 |
| Lake Erie | Lake | native | 86798 |
| Lake Huron | Lake | native | 86798 |
| Lake Michigan | Lake | native | 86798 |
| Lake Ontario | Lake | native | 86798 |
| Mississippi River | River (basin) | native | 78789 |
| Missouri River | River (basin) | native | 78789 |
| Nearctic | Zoogeographic realm | endemic | 5723 |
| Potomac River | River (basin) | native | 27549 |
| Red River of the North | River (basin) | native | 86798 |
| St. Lawrence | River (basin) | native | 5723 |
| Tennessee River | River (basin) | native | 10294 |