| Ecosystem | Type | Status | Ref. |
|---|---|---|---|
| Danube | River (basin) | native | 5723 |
| Great Lakes | Lake | native | 10294 |
| Lake Erie | Lake | native | 120328 |
| Lake Huron | Lake | native | 120328 |
| Lake Ontario | Lake | native | 120328 |
| Lake Superior | Lake | native | 120331 |
| Loire | River (basin) | introduced | 30578 |
| Mississippi River | River (basin) | native | 5723 |
| Missouri River | River (basin) | native | 78789 |
| Nearctic | Zoogeographic realm | endemic | 5723 |
| Palearctic | Zoogeographic realm | introduced | 5723 |
| Rio Grande | River (basin) | extirpated | 78807 |
| St. Lawrence | River (basin) | native | 5723 |
| Tennessee River | River (basin) | native | 79012 |