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| No. | Valid Name | Author | English Name |
| 1. | Profundulus guatemalensis | (Günther, 1866) | |
| 2. | Profundulus kreiseri | Matamoros, Schaefer, Hernández & Chakrabarty, 2012 | Kreiser’s Killifish |
| 3. | Profundulus mixtlanensis | Ornelas-García, Martínez-Ramírez & Doadrio, 2015 | |
| 4. | Profundulus oaxacae | (Meek, 1902) | |
| 5. | Profundulus parentiae | Matamoros, Domínguez-Cisneros, Velázquez-Velázquez & McMahan, 2018 | Parenti’s killifish |
| 6. | Profundulus punctatus | (Günther, 1866) | Oaxaca killifish |